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1k36

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{{STRUCTURE_1k36| PDB=1k36 | SCENE= }}
{{STRUCTURE_1k36| PDB=1k36 | SCENE= }}
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'''NMR Structure of human Epiregulin'''
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===NMR Structure of human Epiregulin===
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==Overview==
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Epiregulin (EPR), a novel member of epidermal growth factor (EGF) family, is a ligand for ErbB-1 and ErbB-4 receptors. The binding affinity of EPR for the receptors is lower than those of other EGF-family ligands. The solution structure of EPR was determined using two-dimensional nuclear magnetic resonance spectroscopy. The secondary structure in the C-terminal domain of EPR is different from other EGF-family ligands because of the lack of hydrogen bonds. The structural difference in the C-terminal domain may provide an explanation for the reduced binding affinity of EPR to the ErbB receptors.
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{{ABSTRACT_PUBMED_14572630}}
==About this Structure==
==About this Structure==
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1K36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K36 OCA].
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1K36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K36 OCA].
==Reference==
==Reference==
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[[Category: Tada, M.]]
[[Category: Tada, M.]]
[[Category: Egf-like fold]]
[[Category: Egf-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:52:17 2008''

Revision as of 04:52, 29 July 2008

Image:1k36.png

Template:STRUCTURE 1k36

NMR Structure of human Epiregulin

Template:ABSTRACT PUBMED 14572630

About this Structure

1K36 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity., Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K, FEBS Lett. 2003 Oct 23;553(3):232-8. PMID:14572630

Page seeded by OCA on Tue Jul 29 07:52:17 2008

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