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3cnf

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{{STRUCTURE_3cnf| PDB=3cnf | SCENE= }}
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'''3.88 Angstrom structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy'''
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===3.88 Angstrom structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy===
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==Overview==
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Cytoplasmic polyhedrosis virus (CPV) is unique within the Reoviridae family in having a turreted single-layer capsid contained within polyhedrin inclusion bodies, yet being fully capable of cell entry and endogenous RNA transcription. Biochemical data have shown that the amino-terminal 79 residues of the CPV turret protein (TP) is sufficient to bring CPV or engineered proteins into the polyhedrin matrix for micro-encapsulation. Here we report the three-dimensional structure of CPV at 3.88 A resolution using single-particle cryo-electron microscopy. Our map clearly shows the turns and deep grooves of alpha-helices, the strand separation in beta-sheets, and densities for loops and many bulky side chains; thus permitting atomic model-building effort from cryo-electron microscopy maps. We observed a helix-to-beta-hairpin conformational change between the two conformational states of the capsid shell protein in the region directly interacting with genomic RNA. We have also discovered a messenger RNA release hole coupled with the mRNA capping machinery unique to CPV. Furthermore, we have identified the polyhedrin-binding domain, a structure that has potential in nanobiotechnology applications.
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(as it appears on PubMed at http://www.pubmed.gov), where 18449192 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18449192}}
==About this Structure==
==About this Structure==
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[[Category: Polyhedrin-binding domain]]
[[Category: Polyhedrin-binding domain]]
[[Category: Turret protein]]
[[Category: Turret protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:37:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:54:03 2008''

Revision as of 04:54, 29 July 2008

Image:3cnf.png

Template:STRUCTURE 3cnf

3.88 Angstrom structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy

Template:ABSTRACT PUBMED 18449192

About this Structure

3CNF is a Protein complex structure of sequences from Bombyx mori cypovirus 1. Full crystallographic information is available from OCA.

Reference

3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy., Yu X, Jin L, Zhou ZH, Nature. 2008 May 15;453(7193):415-9. Epub 2008 Apr 30. PMID:18449192

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