2omm

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{{STRUCTURE_2omm| PDB=2omm | SCENE= }}
{{STRUCTURE_2omm| PDB=2omm | SCENE= }}
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'''GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35'''
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===GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35===
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==Overview==
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Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
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{{ABSTRACT_PUBMED_17468747}}
==About this Structure==
==About this Structure==
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[[Category: Polar zipper]]
[[Category: Polar zipper]]
[[Category: Steric zipper]]
[[Category: Steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:13:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:55:26 2008''

Revision as of 04:55, 29 July 2008

Image:2omm.png

Template:STRUCTURE 2omm

GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35

Template:ABSTRACT PUBMED 17468747

About this Structure

Full crystallographic information is available from OCA.

Reference

Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747

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