1y47

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{{STRUCTURE_1y47| PDB=1y47 | SCENE= }}
{{STRUCTURE_1y47| PDB=1y47 | SCENE= }}
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'''Structural studies of designed alpha-helical hairpins'''
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===Structural studies of designed alpha-helical hairpins===
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==Overview==
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Although the analysis and design of turns that connect the strands in antiparallel beta-hairpins has reached an advanced state, much less is known concerning turns between antiparallel helices in helical hairpins. We have conducted an analysis of the structures and sequence preferences of two types of interhelical turns, each of which connects the two helices by a two-residue linker in an alphaL-beta conformation. Based on this analysis, it became apparent that the turn introduced into a designed four-helix bundle protein, DF1, did not occur within an optimal structural context. DF1 is a dimeric model for the diiron class of proteins. A longer loop with a beta-alphaR-beta conformation was inserted between two helices in the protein, and a sequence was chosen to stabilize its conformation. X-ray crystallography and NMR analysis of the protein showed the structure to be in excellent agreement with design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15713492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15713492}}
==About this Structure==
==About this Structure==
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[[Category: Protein design]]
[[Category: Protein design]]
[[Category: Turn]]
[[Category: Turn]]
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Revision as of 04:55, 29 July 2008

Image:1y47.png

Template:STRUCTURE 1y47

Structural studies of designed alpha-helical hairpins

Template:ABSTRACT PUBMED 15713492

About this Structure

Full crystallographic information is available from OCA.

Reference

Analysis and design of turns in alpha-helical hairpins., Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF, J Mol Biol. 2005 Mar 11;346(5):1441-54. Epub 2005 Jan 13. PMID:15713492

Page seeded by OCA on Tue Jul 29 07:55:34 2008

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