2oud

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{{STRUCTURE_2oud| PDB=2oud | SCENE= }}
{{STRUCTURE_2oud| PDB=2oud | SCENE= }}
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'''Crystal structure of the catalytic domain of human MKP5'''
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===Crystal structure of the catalytic domain of human MKP5===
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==Overview==
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MAP kinase phosphatases (MKPs) have crucial roles in regulating the signaling activity of MAP kinases and are potential targets for drug discovery against human diseases. These enzymes contain a catalytic domain (CD) as well as a binding domain (BD) that help recognize the target MAP kinase. We report here the crystal structures at up to 2.2 A resolution of the BD and CD of human MKP5 and compare them to the known structures from other MKPs. Dramatic structural differences are observed between the BD of MKP5 and that of MKP3 determined previously by NMR. In particular, the cluster of positively charged residues that is important for MAP kinase binding is located in completely different positions in the two structures, with a distance of 25 A between them. Moreover, this cluster is alpha-helical in MKP5, while it forms a loop followed by a beta-strand in MKP3. These large structural differences could be associated with the distinct substrate preferences of these phosphatases, but further studies are needed to confirm this. The CD of MKP5 is observed in an active conformation, and two loops in the active site have backbone shifts of up to 5 A relative to the inactive CDs from other MKPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17400920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17400920}}
==About this Structure==
==About this Structure==
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[[Category: A central five-stranded b-sheet]]
[[Category: A central five-stranded b-sheet]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:40:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:55:58 2008''

Revision as of 04:56, 29 July 2008

Image:2oud.png

Template:STRUCTURE 2oud

Crystal structure of the catalytic domain of human MKP5

Template:ABSTRACT PUBMED 17400920

About this Structure

2OUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5., Tao X, Tong L, Protein Sci. 2007 May;16(5):880-6. Epub 2007 Mar 30. PMID:17400920

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