2if7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2if7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2if7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2if7| PDB=2if7 | SCENE= }}
{{STRUCTURE_2if7| PDB=2if7 | SCENE= }}
-
'''Crystal Structure of NTB-A'''
+
===Crystal Structure of NTB-A===
-
==Overview==
+
<!--
-
The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17045824}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17045824 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17045824}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Ntb-a]]
[[Category: Ntb-a]]
[[Category: Slam6]]
[[Category: Slam6]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:26:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:57:36 2008''

Revision as of 04:57, 29 July 2008

Image:2if7.png

Template:STRUCTURE 2if7

Crystal Structure of NTB-A

Template:ABSTRACT PUBMED 17045824

About this Structure

2IF7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family., Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC, Immunity. 2006 Oct;25(4):559-70. PMID:17045824

Page seeded by OCA on Tue Jul 29 07:57:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2if7"
Personal tools