1pwo

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{{STRUCTURE_1pwo| PDB=1pwo | SCENE= }}
{{STRUCTURE_1pwo| PDB=1pwo | SCENE= }}
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'''Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka'''
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===Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka===
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==Overview==
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Comparison of the crystal structures of three Micropechis ikaheka phospholipase A2 isoenzymes (MiPLA2, MiPLA3 and MiPLA4, which exhibit different levels of pharmacological effects) shows that their C-terminus (residues 110-124) is the most variable. M-Type receptor binding affinity of the isoenzymes has also been investigated and MiPLA4 binds to the rabbit M-type receptor with high affinity. Examination of surface charges of the isoenzymes reveals a trend of increase in positive charges with potency. The isoenzymes are shown to oligomerize in a concentration-dependent manner in a semi-denaturing gel. The C-termini of the medium (MiPLA4) and highly potent (MiPLA2) isoenzyme molecules cluster together, forming a highly exposed area. A BLAST search using the sequence of the most potent MiPLA2 results in high similarity to Staphylococcus aureus clotting factor A and cadherin 11. This might explain the myotoxicity, anticoagulant and hemoglobinuria effects of MiPLA2s.
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(as it appears on PubMed at http://www.pubmed.gov), where 15720395 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15720395}}
==About this Structure==
==About this Structure==
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[[Category: Pancreatic loop]]
[[Category: Pancreatic loop]]
[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:34:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:57:52 2008''

Revision as of 04:57, 29 July 2008

Image:1pwo.png

Template:STRUCTURE 1pwo

Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka

Template:ABSTRACT PUBMED 15720395

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes., Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K, FEBS J. 2005 Mar;272(5):1211-20. PMID:15720395

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