2ayu

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[[Image:2ayu.gif|left|200px]]
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{{STRUCTURE_2ayu| PDB=2ayu | SCENE= }}
{{STRUCTURE_2ayu| PDB=2ayu | SCENE= }}
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'''The structure of nucleosome assembly protein suggests a mechanism for histone binding and shuttling'''
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===The structure of nucleosome assembly protein suggests a mechanism for histone binding and shuttling===
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==Overview==
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Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, thereby affecting the transcription of many genes. The 3.0 A crystal structure of yeast NAP-1 reveals a previously uncharacterized fold with implications for histone binding and shuttling. A long alpha-helix is responsible for homodimerization via a previously uncharacterized antiparallel non-coiled-coil, and an alpha/beta domain is implicated in protein-protein interaction. A nuclear export sequence that is embedded in the dimerization helix is almost completely masked by an accessory domain that contains several target sites for casein kinase II. The four-stranded antiparallel beta-sheet that characterizes the alpha/beta domain is found in all histone chaperones, despite the absence of homology in sequence, structural context, or quaternary structure. To our knowledge, this is the first structure of a member of the large NAP family of proteins and suggests a mechanism by which the shuttling of histones to and from the nucleus is regulated.
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The line below this paragraph, {{ABSTRACT_PUBMED_16432217}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16432217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16432217}}
==About this Structure==
==About this Structure==
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[[Category: Park, Y J.]]
[[Category: Park, Y J.]]
[[Category: Histone chaperone]]
[[Category: Histone chaperone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:38:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:02:01 2008''

Revision as of 05:02, 29 July 2008

Image:2ayu.png

Template:STRUCTURE 2ayu

The structure of nucleosome assembly protein suggests a mechanism for histone binding and shuttling

Template:ABSTRACT PUBMED 16432217

About this Structure

2AYU is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of nucleosome assembly protein 1., Park YJ, Luger K, Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1248-53. Epub 2006 Jan 23. PMID:16432217

Page seeded by OCA on Tue Jul 29 08:02:01 2008

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