1zyk

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{{STRUCTURE_1zyk| PDB=1zyk | SCENE= }}
{{STRUCTURE_1zyk| PDB=1zyk | SCENE= }}
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'''Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium'''
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===Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium===
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==Overview==
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The metabolic synthesis and degradation of essential nucleotide compounds are primarily carried out by phosphoribosyltransferases (PRT) and nucleoside phosphorylases (NP), respectively. Despite the resemblance of their reactions, five classes of PRTs and NPs exist, where anthranilate PRT (AnPRT) constitutes the only evolutionary link between synthesis and degradation processes. We have characterized the active site of dimeric AnPRT from Sulfolobus solfataricus by elucidating crystal structures of the wild-type enzyme complexed to its two natural substrates anthranilate and 5-phosphoribosyl-1-pyrophosphate/Mg(2+). These bind into two different domains within each protomer and are brought together during catalysis by rotational domain motions as shown by small angle x-ray scattering data. Steady-state kinetics of mutated AnPRT variants address the role of active site residues in binding and catalysis. Results allow the comparative analysis of PRT and pyrimidine NP families and expose related structural motifs involved in nucleotide/nucleoside recognition by these enzyme families.
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(as it appears on PubMed at http://www.pubmed.gov), where 16714288 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16714288}}
==About this Structure==
==About this Structure==
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[[Category: Prpp]]
[[Category: Prpp]]
[[Category: Trpd]]
[[Category: Trpd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:14:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:02:42 2008''

Revision as of 05:02, 29 July 2008

Image:1zyk.png

Template:STRUCTURE 1zyk

Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium

Template:ABSTRACT PUBMED 16714288

About this Structure

1ZYK is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus., Marino M, Deuss M, Svergun DI, Konarev PV, Sterner R, Mayans O, J Biol Chem. 2006 Jul 28;281(30):21410-21. Epub 2006 May 19. PMID:16714288

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