2imm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2imm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2imm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2imm| PDB=2imm | SCENE= }}
{{STRUCTURE_2imm| PDB=2imm | SCENE= }}
-
'''Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant'''
+
===Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant===
-
==Overview==
+
<!--
-
We report the solution of the crystal structure of a mutant of the immunoglobulin VL domain of the antibody McPC603, in which the complementarity-determining region 1 segment is replaced with that of a different antibody. The wild-type and mutant crystal structures have been refined to a crystallographic R-factor of 14.9% at a nominal resolution of 1.97 A. A detailed description of the structures is given. Crystal packing results in a dimeric association of domains, in a fashion closely resembling that of an Fv fragment. The comparison of this VL domain with the same domain in the Fab fragment of McPC603 shows that the structure of an immunoglobulin VL domain is largely independent of its mode of association, even in places where the inter-subunit contacts are not conserved between VL and VH. In all three complementarity-determining regions we observe conformations that would not have been predicted by the canonical structure hypothesis. Significant differences between the VL domain dimer and the Fab fragment in the third complementarity-determining region show that knowledge of the structure of the dimerization partner and its exact mode of association may be needed to predict the precise conformation of antigen-binding loops.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1602480}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1602480 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1602480}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Steipe, B.]]
[[Category: Steipe, B.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:39:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:05:38 2008''

Revision as of 05:05, 29 July 2008

Image:2imm.png

Template:STRUCTURE 2imm

Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant

Template:ABSTRACT PUBMED 1602480

About this Structure

2IMM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant., Steipe B, Pluckthun A, Huber R, J Mol Biol. 1992 Jun 5;225(3):739-53. PMID:1602480

Page seeded by OCA on Tue Jul 29 08:05:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2imm"
Personal tools