2rcn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2rcn.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2rcn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2rcn| PDB=2rcn | SCENE= }}
{{STRUCTURE_2rcn| PDB=2rcn | SCENE= }}
-
'''Crystal Structure of the Ribosomal interacting GTPase YjeQ from the Enterobacterial species Salmonella Typhimurium.'''
+
===Crystal Structure of the Ribosomal interacting GTPase YjeQ from the Enterobacterial species Salmonella Typhimurium.===
-
==Overview==
+
<!--
-
The YjeQ class of P-loop GTPases assist in ribosome biogenesis and also bind to the 30S subunit of mature ribosomes. YjeQ ribosomal binding is GTP-dependent and thought to specifically direct protein synthesis, although the nature of the upstream signal causing this event in vivo is as yet unknown. The attenuating effect of YjeQ mutants on bacterial growth in Escherichia coli makes it a potential target for novel antimicrobial agents. In order to further explore the structure and function of YjeQ, the isolation, crystallization and structure determination of YjeQ from the enterobacterial species Salmonella typhimurium (StYjeQ) is reported. Whilst the overall StYjeQ fold is similar to those of the previously reported Thematoga maritima and Bacillus subtilis orthologues, particularly the GTPase domain, there are larger differences in the three OB folds. Although the zinc-finger secondary structure is conserved, significant sequence differences alter the nature of the external surface in each case and may reflect varying signalling pathways. Therefore, it may be easier to develop YjeQ-specific inhibitors that target the N- and C-terminal regions, disrupting the metabolic connectivity rather than the GTPase activity. The availability of coordinates for StYjeQ will provide a significantly improved basis for threading Gram-negative orthologue sequences and in silico compound-screening studies, with the potential for the development of species-selective drugs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18007041}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18007041 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18007041}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Yjeq]]
[[Category: Yjeq]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:38:53 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:09:11 2008''

Revision as of 05:09, 29 July 2008

Image:2rcn.png

Template:STRUCTURE 2rcn

Crystal Structure of the Ribosomal interacting GTPase YjeQ from the Enterobacterial species Salmonella Typhimurium.

Template:ABSTRACT PUBMED 18007041

About this Structure

2RCN is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium., Nichols CE, Johnson C, Lamb HK, Lockyer M, Charles IG, Hawkins AR, Stammers DK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt, 11):922-8. Epub 2007 Oct 24. PMID:18007041

Page seeded by OCA on Tue Jul 29 08:09:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rcn"
Personal tools