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1mqt

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[[Image:1mqt.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1mqt| PDB=1mqt | SCENE= }}
{{STRUCTURE_1mqt| PDB=1mqt | SCENE= }}
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'''Swine Vesicular Disease Virus coat protein'''
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===Swine Vesicular Disease Virus coat protein===
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==Overview==
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The structure of swine vesicular disease virus (SVDV) was solved and refined at a 3.0-A resolution by X-ray crystallography to gain information about the role of sequence changes that occurred as this virus evolved from the parental human pathogen coxsackievirus B5 (CVB5). These amino acid substitutions can be clustered in five distinct regions: (i) the antigenic sites, (ii) the hydrophobic pocket of the VP1 beta-sandwich, (iii) the putative CAR binding site, (iv) the putative heparan sulfate binding site, and (v) the fivefold axis. The VP1 pocket is occupied by a branched pocket factor, apparently different from that present in the closely related virus CVB3 and in other picornaviruses. This finding may be relevant for the design of new antiviral compounds against this site. Density consistent with the presence of ions was observed on the fivefold and threefold axes. The structure also provided an accurate description of the putative receptor binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 12941886 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12941886}}
==About this Structure==
==About this Structure==
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[[Category: Svdv coat protein]]
[[Category: Svdv coat protein]]
[[Category: Swine vesicular disease virus]]
[[Category: Swine vesicular disease virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:12:21 2008''

Revision as of 05:12, 29 July 2008

Image:1mqt.png

Template:STRUCTURE 1mqt

Swine Vesicular Disease Virus coat protein

Template:ABSTRACT PUBMED 12941886

About this Structure

1MQT is a Protein complex structure of sequences from Swine vesicular disease virus. Full crystallographic information is available from OCA.

Reference

Structure of swine vesicular disease virus: mapping of changes occurring during adaptation of human coxsackie B5 virus to infect swine., Verdaguer N, Jimenez-Clavero MA, Fita I, Ley V, J Virol. 2003 Sep;77(18):9780-9. PMID:12941886

Page seeded by OCA on Tue Jul 29 08:12:21 2008

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