1pd1

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[[Image:1pd1.gif|left|200px]]
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{{STRUCTURE_1pd1| PDB=1pd1 | SCENE= }}
{{STRUCTURE_1pd1| PDB=1pd1 | SCENE= }}
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'''Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide containing the DxE cargo sorting signal of yeast Sys1 protein'''
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===Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide containing the DxE cargo sorting signal of yeast Sys1 protein===
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==Overview==
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The COPII coat buds transport vesicles from the endoplasmic reticulum that incorporate cargo and SNARE molecules. Here, we show that recognition of the ER-Golgi SNAREs Bet1, Sed5, and Sec22 occurs through three binding sites on the Sec23/24 subcomplex of yeast COPII. The A site binds to the YNNSNPF motif of Sed5. The B site binds to Lxx-L/M-E sequences present in both the Bet1 and Sed5 molecules, as well as to the DxE cargo-sorting signal. A third, spatially distinct site binds to Sec22. COPII selects the free v-SNARE form of Bet1 because the LxxLE sequence is sequestered in the four-helix bundle of the v-/t-SNARE complex. COPII favors Sed5 within the Sed5/Bos1/Sec22 t-SNARE complex because t-SNARE assembly removes autoinhibitory contacts to expose the YNNSNPF motif. The COPII coat seems to be a specific conductor of the fusogenic forms of these SNAREs, suggesting how vesicle fusion specificity may be programmed during budding.
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The line below this paragraph, {{ABSTRACT_PUBMED_12941276}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12941276 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12941276}}
==About this Structure==
==About this Structure==
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[[Category: Mossessova, E.]]
[[Category: Mossessova, E.]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:57:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:19:29 2008''

Revision as of 05:19, 29 July 2008

Image:1pd1.png

Template:STRUCTURE 1pd1

Crystal structure of the COPII coat subunit, Sec24, complexed with a peptide containing the DxE cargo sorting signal of yeast Sys1 protein

Template:ABSTRACT PUBMED 12941276

About this Structure

1PD1 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

SNARE selectivity of the COPII coat., Mossessova E, Bickford LC, Goldberg J, Cell. 2003 Aug 22;114(4):483-95. PMID:12941276

Page seeded by OCA on Tue Jul 29 08:19:29 2008

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