1r0d

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{{STRUCTURE_1r0d| PDB=1r0d | SCENE= }}
{{STRUCTURE_1r0d| PDB=1r0d | SCENE= }}
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'''HIP1R THATCH DOMAIN CORE'''
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===HIP1R THATCH DOMAIN CORE===
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==Overview==
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Huntingtin-interacting protein-1 related (HIP1R) has a crucial protein-trafficking role, mediating associations between actin and clathrin-coated structures at the plasma membrane and trans-Golgi network. Here, we characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain. The 1.9-A crystal structure of the human HIP1R THATCH core reveals a large sequence-conserved surface patch created primarily by residues from the third and fourth helices of a unique five-helix bundle. Point mutations of seven contiguous patch residues produced significant decreases in F-actin binding. We also show that THATCH domains have a conserved C-terminal latch capable of oligomerizing the core, thereby modulating F-actin engagement. Collectively, these results establish a framework for investigating the links between endocytosis and actin dynamics mediated by THATCH domain-containing proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16415883 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16415883}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:55:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:20:26 2008''

Revision as of 05:20, 29 July 2008

Image:1r0d.png

Template:STRUCTURE 1r0d

HIP1R THATCH DOMAIN CORE

Template:ABSTRACT PUBMED 16415883

About this Structure

1R0D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural definition of the F-actin-binding THATCH domain from HIP1R., Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH, Nat Struct Mol Biol. 2006 Feb;13(2):121-30. Epub 2006 Jan 15. PMID:16415883

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