2oct

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oct.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2oct.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oct| PDB=2oct | SCENE= }}
{{STRUCTURE_2oct| PDB=2oct | SCENE= }}
-
'''Stefin B (Cystatin B) tetramer'''
+
===Stefin B (Cystatin B) tetramer===
-
==Overview==
+
<!--
-
Here we present the tetrameric structure of stefin B, which is the result of a process by which two domain-swapped dimers of stefin B are transformed into tetramers. The transformation involves a previously unidentified process of extensive intermolecular contacts, termed hand shaking, which occurs concurrently with trans to cis isomerization of proline 74. This proline residue is widely conserved throughout the cystatin superfamily, a member of which, human cystatin C, is the key protein in cerebral amyloid angiopathy. These results are consistent with the hypothesis that isomerization of proline residues can play a decisive role in amyloidogenesis.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17217964}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17217964 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17217964}}
==Disease==
==Disease==
Line 34: Line 38:
[[Category: Proline isomerization]]
[[Category: Proline isomerization]]
[[Category: Stefin]]
[[Category: Stefin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:37:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:20:52 2008''

Revision as of 05:20, 29 July 2008

Image:2oct.png

Template:STRUCTURE 2oct

Contents

Stefin B (Cystatin B) tetramer

Template:ABSTRACT PUBMED 17217964

Disease

Known disease associated with this structure: Epilepsy, progressive myoclonic 1 OMIM:[601145]

About this Structure

2OCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Essential role of proline isomerization in stefin B tetramer formation., Jenko Kokalj S, Guncar G, Stern I, Morgan G, Rabzelj S, Kenig M, Staniforth RA, Waltho JP, Zerovnik E, Turk D, J Mol Biol. 2007 Mar 9;366(5):1569-79. Epub 2006 Dec 16. PMID:17217964

Page seeded by OCA on Tue Jul 29 08:20:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oct"
Personal tools