2ahx

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{{STRUCTURE_2ahx| PDB=2ahx | SCENE= }}
{{STRUCTURE_2ahx| PDB=2ahx | SCENE= }}
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'''Crystal structure of ErbB4/HER4 extracellular domain'''
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===Crystal structure of ErbB4/HER4 extracellular domain===
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==Overview==
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The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play fundamental roles in cell growth and differentiation events in embryonic and adult tissues, and inappropriate ErbB activity has been implicated in several human cancers. We report here the 2.4 A crystal structure of the extracellular region of human ErbB4 in the absence of ligand and show that it adopts a tethered conformation similar to inactive forms of ErbB1 and ErbB3. This structure completes the gallery of unliganded ErbB receptors and demonstrates that all human ligand-binding ErbBs adopt the autoinhibited conformation. We also show that the binding of neuregulin-1beta to ErbB4 and ErbB3 and the binding of betacellulin to both ErbB4 and ErbB1 does not decrease at low pH, unlike the binding of epidermal growth factor and transforming growth factor-alpha to ErbB1. These results indicate an important role for ligand in determining pH-dependent binding and may explain different responses observed when the same ErbB receptor is stimulated by different ligands.
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(as it appears on PubMed at http://www.pubmed.gov), where 16203964 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16203964}}
==About this Structure==
==About this Structure==
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[[Category: Neuregulin]]
[[Category: Neuregulin]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:23:23 2008''

Revision as of 05:23, 29 July 2008

Image:2ahx.png

Template:STRUCTURE 2ahx

Crystal structure of ErbB4/HER4 extracellular domain

Template:ABSTRACT PUBMED 16203964

About this Structure

2AHX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand., Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ, Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15024-9. Epub 2005 Oct 3. PMID:16203964

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