1u7w

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{{STRUCTURE_1u7w| PDB=1u7w | SCENE= }}
{{STRUCTURE_1u7w| PDB=1u7w | SCENE= }}
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'''Phosphopantothenoylcysteine synthetase from E. coli, CTP-complex'''
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===Phosphopantothenoylcysteine synthetase from E. coli, CTP-complex===
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==Overview==
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Phosphopantothenoylcysteine (PPC) synthetase forms a peptide bond between 4'-phosphopantothenate and cysteine in coenzyme A biosynthesis. PPC synthetases fall into two classes: eukaryotic, ATP-dependent and eubacterial, CTP-dependent enzymes. We describe the first crystal structure of E. coli PPC synthetase as a prototype of bacterial, CTP-dependent PPC synthetases. Structures of the apo-form and the synthetase complexed with CTP, the activated acyl-intermediate, 4'-phosphopantothenoyl-CMP, and with the reaction product CMP provide snapshots along the reaction pathway and detailed insight into substrate binding and the reaction mechanism of peptide bond formation. Binding of the phosphopantothenate moiety of the acyl-intermediate in a cleft at the C-terminal end of the central beta sheet of the dinucleotide binding fold is accomplished by an otherwise flexible flap. A second disordered loop may control access of cysteine to the active site. The conservation of functionalities involved in substrate binding and catalysis provides insight into similarities and differences of prokaryotic and eukaryotic PPC synthetases.
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{{ABSTRACT_PUBMED_15530362}}
==About this Structure==
==About this Structure==
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[[Category: Steinbacher, S.]]
[[Category: Steinbacher, S.]]
[[Category: Coenzyme a biosynthesis]]
[[Category: Coenzyme a biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:23:56 2008''

Revision as of 05:23, 29 July 2008

Image:1u7w.png

Template:STRUCTURE 1u7w

Phosphopantothenoylcysteine synthetase from E. coli, CTP-complex

Template:ABSTRACT PUBMED 15530362

About this Structure

1U7W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase., Stanitzek S, Augustin MA, Huber R, Kupke T, Steinbacher S, Structure. 2004 Nov;12(11):1977-88. PMID:15530362

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