1pxe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pxe.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pxe.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pxe| PDB=1pxe | SCENE= }}
{{STRUCTURE_1pxe| PDB=1pxe | SCENE= }}
-
'''Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1'''
+
===Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1===
-
==Overview==
+
<!--
-
The structure of a CCHHC zinc-binding domain from neural zinc finger factor-1 (NZF-1) has been determined in solution though the use of NMR methods. This domain is a member of a family of domains that have the Cys-X(4)-Cys-X(4)-His-X(7)-His-X(5)-Cys consensus sequence. The structure determination reveals a novel fold based around a zinc(II) ion coordinated to three Cys residues and the second of the two conserved His residues. The other His residue is stacked between the metal-coordinated His residue and a relatively conserved aromatic residue. Analysis of His to Gln sequence variants reveals that both His residues are required for the formation of a well-defined structure, but neither is required for high-affinity metal binding at a tetrahedral site. The structure suggests that a two-domain protein fragment and a double-stranded DNA binding site may interact with a common two-fold axis relating the two domains and the two half-sites of the DNA-inverted repeat.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14744132}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14744132 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14744132}}
==About this Structure==
==About this Structure==
-
1PXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA].
+
1PXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA].
==Reference==
==Reference==
Line 28: Line 32:
[[Category: Dna binding domain]]
[[Category: Dna binding domain]]
[[Category: Neural zinc finger factor-1]]
[[Category: Neural zinc finger factor-1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:35:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:27:26 2008''

Revision as of 05:27, 29 July 2008

Image:1pxe.png

Template:STRUCTURE 1pxe

Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1

Template:ABSTRACT PUBMED 14744132

About this Structure

1PXE is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding., Berkovits-Cymet HJ, Amann BT, Berg JM, Biochemistry. 2004 Feb 3;43(4):898-903. PMID:14744132

Page seeded by OCA on Tue Jul 29 08:27:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pxe"
Personal tools