2ocp

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{{STRUCTURE_2ocp| PDB=2ocp | SCENE= }}
{{STRUCTURE_2ocp| PDB=2ocp | SCENE= }}
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'''Crystal Structure of Human Deoxyguanosine Kinase'''
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===Crystal Structure of Human Deoxyguanosine Kinase===
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==Overview==
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Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and activate a number of medically important nucleoside analogs. Here we report the structure of the Drosophila deoxyribonucleoside kinase with deoxycytidine bound at the nucleoside binding site and that of the human deoxyguanosine kinase with ATP at the nucleoside substrate binding site. Compared to the human kinase, the Drosophila kinase has a wider substrate cleft, which may be responsible for the broad substrate specificity of this enzyme. The human deoxyguanosine kinase is highly specific for purine substrates; this is apparently due to the presence of Arg 118, which provides favorable hydrogen bonding interactions with the substrate. The two new structures provide an explanation for the substrate specificity of cellular deoxyribonucleoside kinases.
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{{ABSTRACT_PUBMED_11427893}}
==About this Structure==
==About this Structure==
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[[Category: Ramaswamy, S.]]
[[Category: Ramaswamy, S.]]
[[Category: Protein-nucleotide complex]]
[[Category: Protein-nucleotide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:27:54 2008''

Revision as of 05:27, 29 July 2008

Image:2ocp.png

Template:STRUCTURE 2ocp

Crystal Structure of Human Deoxyguanosine Kinase

Template:ABSTRACT PUBMED 11427893

About this Structure

2OCP is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1jag. Full crystallographic information is available from OCA.

Reference

Structural basis for substrate specificities of cellular deoxyribonucleoside kinases., Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H, Nat Struct Biol. 2001 Jul;8(7):616-20. PMID:11427893

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