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1zx4

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{{STRUCTURE_1zx4| PDB=1zx4 | SCENE= }}
{{STRUCTURE_1zx4| PDB=1zx4 | SCENE= }}
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'''Structure of ParB bound to DNA'''
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===Structure of ParB bound to DNA===
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==Overview==
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The faithful inheritance of genetic information, which is essential for all organisms, requires accurate DNA partition (segregation) at cell division. In prokaryotes, partition is mediated by par systems, for which the P1 plasmid system of Escherichia coli is a prototype comprising a partition site and two proteins, ParA and ParB. To form the partition complex necessary for segregation, P1 ParB must recognize a complicated arrangement of A-box and B-box DNA motifs located on opposite ends of a sharply bent parS partition site of approximately 74 bp (refs 3-7). Here we describe structures of ParB bound to partition sites. ParB forms an asymmetric dimer with extended amino-terminal HTH (helix-turn-helix) domains that contact A-boxes. The two HTH domains emanate from a dimerized DNA-binding module composed of a six-stranded beta-sheet coiled-coil that binds B-boxes. Strikingly, these individual DNA-binding modules rotate freely about a flexible linker, enabling them to contact several arrangements of A- and B-boxes. Most notably, each DNA-binding element binds to and thus bridges adjacent DNA duplexes. These unique structural features of ParB explain how this protein can bind complex arrays of A- and B-box elements on adjacent DNA arms of the looped partition site.
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(as it appears on PubMed at http://www.pubmed.gov), where 16306995 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16306995}}
==About this Structure==
==About this Structure==
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[[Category: Partition]]
[[Category: Partition]]
[[Category: Plasmid]]
[[Category: Plasmid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:11:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:28:24 2008''

Revision as of 05:28, 29 July 2008

Image:1zx4.png

Template:STRUCTURE 1zx4

Structure of ParB bound to DNA

Template:ABSTRACT PUBMED 16306995

About this Structure

1ZX4 is a Single protein structure of sequence from Enterobacteria phage p1. Full crystallographic information is available from OCA.

Reference

Structures of ParB bound to DNA reveal mechanism of partition complex formation., Schumacher MA, Funnell BE, Nature. 2005 Nov 24;438(7067):516-9. PMID:16306995

Page seeded by OCA on Tue Jul 29 08:28:24 2008

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