1w2k

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(New page: 200px<br /> <applet load="1w2k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w2k, resolution 3.00&Aring;" /> '''TF7A_4380 COMPLEX''...)
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Revision as of 18:41, 29 October 2007

Image:1w2k.gif

1w2k, resolution 3.00Å

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TF7A_4380 COMPLEX

Overview

Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.

About this Structure

1W2K is a [Protein complex] structure of sequences from [Homo sapiens] with FUC, BGC, CA, CAC and 380 as [ligands]. Active as [[1]], with EC number [3.4.21.21]. Full crystallographic information is available from [OCA].

Reference

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864

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