1pgy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pgy.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1pgy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pgy| PDB=1pgy | SCENE= }}
{{STRUCTURE_1pgy| PDB=1pgy | SCENE= }}
-
'''Solution structure of the UBA domain in Saccharomyces cerevisiae protein, Swa2p'''
+
===Solution structure of the UBA domain in Saccharomyces cerevisiae protein, Swa2p===
-
==Overview==
+
<!--
-
The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid trafficking. While investigating the 287-residue N-terminal region of Swa2p, we found a single stably folded domain between residues 140 and 180. Using binding assays and structural analysis, we established this to be a ubiquitin-associated (UBA) domain, unidentified by bioinformatics of the yeast genome. We determined the solution structure of this Swa2p domain and found a characteristic three-helix UBA fold. Comparisons of structures of known UBA folds reveal that the position of the third helix is quite variable. This helix in Swa2p UBA contains a bulkier tyrosine in place of smaller residues found in other UBAs and cannot pack as close to the second helix. The molecular surface of Swa2p UBA has a mostly negative potential, with a single hydrophobic surface patch found also in the UBA domains of human protein, HHR23A. The presence of a UBA domain implicates Swa2p in novel roles involving ubiquitin and ubiquitinated substrates. We propose that Swa2p is a multifunctional protein capable of recognizing several proteins through its protein-protein recognition domains.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14997574}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14997574 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14997574}}
==About this Structure==
==About this Structure==
-
1PGY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGY OCA].
+
1PGY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGY OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin-associated domain]]
[[Category: Ubiquitin-associated domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:04:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:31:27 2008''

Revision as of 05:31, 29 July 2008

Image:1pgy.png

Template:STRUCTURE 1pgy

Solution structure of the UBA domain in Saccharomyces cerevisiae protein, Swa2p

Template:ABSTRACT PUBMED 14997574

About this Structure

1PGY is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae., Chim N, Gall WE, Xiao J, Harris MP, Graham TR, Krezel AM, Proteins. 2004 Mar 1;54(4):784-93. PMID:14997574

Page seeded by OCA on Tue Jul 29 08:31:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pgy"
Personal tools