2pzy

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[[Image:2pzy.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2pzy| PDB=2pzy | SCENE= }}
{{STRUCTURE_2pzy| PDB=2pzy | SCENE= }}
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'''Structure of MK2 Complexed with Compound 76'''
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===Structure of MK2 Complexed with Compound 76===
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==Overview==
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The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-loop and the hinge region of MK2a.
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The line below this paragraph, {{ABSTRACT_PUBMED_17576063}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17576063 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17576063}}
==About this Structure==
==About this Structure==
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[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:05:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:32:18 2008''

Revision as of 05:32, 29 July 2008

Image:2pzy.png

Template:STRUCTURE 2pzy

Structure of MK2 Complexed with Compound 76

Template:ABSTRACT PUBMED 17576063

About this Structure

2PZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors., Wu JP, Wang J, Abeywardane A, Andersen D, Emmanuel M, Gautschi E, Goldberg DR, Kashem MA, Lukas S, Mao W, Martin L, Morwick T, Moss N, Pargellis C, Patel UR, Patnaude L, Peet GW, Skow D, Snow RJ, Ward Y, Werneburg B, White A, Bioorg Med Chem Lett. 2007 Aug 15;17(16):4664-9. Epub 2007 Jun 7. PMID:17576063

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