2bl6

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[[Image:2bl6.gif|left|200px]]
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{{Seed}}
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[[Image:2bl6.png|left|200px]]
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{{STRUCTURE_2bl6| PDB=2bl6 | SCENE= }}
{{STRUCTURE_2bl6| PDB=2bl6 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE ZN COMPLEX OF EIAV NCP11(22-58) PEPTIDE, INCLUDING TWO CCHC ZN-BINDING MOTIFS.'''
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===SOLUTION STRUCTURE OF THE ZN COMPLEX OF EIAV NCP11(22-58) PEPTIDE, INCLUDING TWO CCHC ZN-BINDING MOTIFS.===
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==Overview==
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Lentiviral nucleocapsid proteins are a class of multifunctional proteins that play an essential role in RNA packaging and viral infectivity. They contain two CX(2)CX(4)HX(4)C zinc binding motifs connected by a basic linker of variable length. The 3D structure of a 37-aa peptide corresponding to sequence 22-58 from lentiviral EIAV nucleocapsid protein NCp11, complexed with zinc, has been determined by 2D (1)H NMR spectroscopy, simulated annealing, and molecular dynamics. The solution structure consists of two zinc binding domains held together by a five-residue basic linker Arg(38)-Ala-Pro-Lys-Val(42) that allows for spatial proximity between the two finger domains. Observed linker folding is stabilized by H bonded secondary structure elements, resulting in an Omega-shaped central region, asymmetrically centered on the linker. The conformational differences and similarities with other NC zinc binding knuckles have been systematically analyzed. The two CCHC motifs, both characterized by a peculiar Pro-Gly sequence preceding the His residue, although preserving Zn-binding geometry and chirality of other known NC proteins, exhibit local fold differences both between each other and in comparison with other previously characterized retroviral CCHC motifs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16634633}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16634633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16634633}}
==About this Structure==
==About this Structure==
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2BL6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL6 OCA].
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2BL6 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BL6 OCA].
==Reference==
==Reference==
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[[Category: Polyprotein]]
[[Category: Polyprotein]]
[[Category: Retrovirus zinc finger-like domain]]
[[Category: Retrovirus zinc finger-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:26:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:32:56 2008''

Revision as of 05:32, 29 July 2008

Image:2bl6.png

Template:STRUCTURE 2bl6

SOLUTION STRUCTURE OF THE ZN COMPLEX OF EIAV NCP11(22-58) PEPTIDE, INCLUDING TWO CCHC ZN-BINDING MOTIFS.

Template:ABSTRACT PUBMED 16634633

About this Structure

2BL6 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structural features in EIAV NCp11: a lentivirus nucleocapsid protein with a short linker., Amodeo P, Castiglione Morelli MA, Ostuni A, Battistuzzi G, Bavoso A, Biochemistry. 2006 May 2;45(17):5517-26. PMID:16634633

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