1zy3

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[[Image:1zy3.gif|left|200px]]
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{{STRUCTURE_1zy3| PDB=1zy3 | SCENE= }}
{{STRUCTURE_1zy3| PDB=1zy3 | SCENE= }}
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'''Structural model of complex of Bcl-w protein with Bid BH3-peptide'''
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===Structural model of complex of Bcl-w protein with Bid BH3-peptide===
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==Overview==
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A peptide corresponding to the BH3 region of the proapoptotic protein, BID, could be bound in the cleft of the antiapoptotic protein, BCL-w. This binding induced major conformational rearrangements in both the peptide and protein components of the complex and led to the displacement and unfolding of the BCL-w C-terminal alpha-helix. The structure of BCL-w with a bound BID-BH3 peptide was determined using NMR spectroscopy and molecular docking. These studies confirmed that a region of 16 residues of the BID-BH3 peptide is responsible for its strong binding to BCL-w and BCL-x(L). The interactions of BCL-w and the BID-BH3 peptide complex with dodecylphosphocholine micelles were characterized and showed that the conformational change of BCL-w upon lipid binding occurred at the same time as the release and unfolding of the BH3 peptide.
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The line below this paragraph, {{ABSTRACT_PUBMED_16475813}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16475813 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16475813}}
==About this Structure==
==About this Structure==
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1ZY3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA].
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1ZY3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA].
==Reference==
==Reference==
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[[Category: Bcl-w]]
[[Category: Bcl-w]]
[[Category: Bh3-peptide]]
[[Category: Bh3-peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:13:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:37:32 2008''

Revision as of 05:37, 29 July 2008

Image:1zy3.png

Template:STRUCTURE 1zy3

Structural model of complex of Bcl-w protein with Bid BH3-peptide

Template:ABSTRACT PUBMED 16475813

About this Structure

1ZY3 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles., Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K, Biochemistry. 2006 Feb 21;45(7):2250-6. PMID:16475813

Page seeded by OCA on Tue Jul 29 08:37:32 2008

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