1s69

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{{STRUCTURE_1s69| PDB=1s69 | SCENE= }}
{{STRUCTURE_1s69| PDB=1s69 | SCENE= }}
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'''The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand'''
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===The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand===
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==Overview==
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The crystal structures of cyanide and azide-bound forms of the truncated hemoglobin from Synechocystis are presented at 1.8 angstroms resolution. A comparison with the structure of the endogenously liganded protein reveals a conformational shift unprecedented in hemoglobins, and provides the first picture of a hexacoordinate hemoglobin in both the bis-histidyl and the exogenously coordinated states. The structural changes between the different conformations are confined to two regions of the protein; the B helix, and the E helix, including the EF loop. A molecular "hinge" controlling movement of the E helix is observed in the EF loop, which is composed of three principal structural elements: Arg64, the heme-d-propionate, and a three-residue extension of the F helix. Additional features of the structural transition between the two protein conformations are discussed as they relate to the complex ligand-binding behavior observed in hexacoordinate hemoglobins, and the potential physiological function of this class of proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15289104}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15289104 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15289104}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen binding]]
[[Category: Oxygen binding]]
[[Category: Truncated]]
[[Category: Truncated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:21:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:40:29 2008''

Revision as of 05:40, 29 July 2008

Image:1s69.png

Template:STRUCTURE 1s69

The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand

Template:ABSTRACT PUBMED 15289104

About this Structure

1S69 is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin., Trent JT 3rd, Kundu S, Hoy JA, Hargrove MS, J Mol Biol. 2004 Aug 20;341(4):1097-108. PMID:15289104

Page seeded by OCA on Tue Jul 29 08:40:29 2008

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