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2osz

From Proteopedia

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[[Image:2osz.gif|left|200px]]
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{{STRUCTURE_2osz| PDB=2osz | SCENE= }}
{{STRUCTURE_2osz| PDB=2osz | SCENE= }}
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'''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding'''
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===Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding===
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==Overview==
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The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.
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(as it appears on PubMed at http://www.pubmed.gov), where 17379812 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17379812}}
==About this Structure==
==About this Structure==
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[[Category: Nucleoporin]]
[[Category: Nucleoporin]]
[[Category: Structure]]
[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:35:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:41:21 2008''

Revision as of 05:41, 29 July 2008

Image:2osz.png

Template:STRUCTURE 2osz

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding

Template:ABSTRACT PUBMED 17379812

About this Structure

2OSZ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding., Melcak I, Hoelz A, Blobel G, Science. 2007 Mar 23;315(5819):1729-32. PMID:17379812

Page seeded by OCA on Tue Jul 29 08:41:21 2008

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