1o08

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{{Seed}}
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{{STRUCTURE_1o08| PDB=1o08 | SCENE= }}
{{STRUCTURE_1o08| PDB=1o08 | SCENE= }}
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'''Structure of Pentavalent Phosphorous Intermediate of an Enzyme Catalyzed Phosphoryl transfer Reaction observed on cocrystallization with Glucose 1-phosphate'''
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===Structure of Pentavalent Phosphorous Intermediate of an Enzyme Catalyzed Phosphoryl transfer Reaction observed on cocrystallization with Glucose 1-phosphate===
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==Overview==
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Enzymes provide enormous rate enhancements, unmatched by any other type of catalyst. The stabilization of high-energy states along the reaction coordinate is the crux of the catalytic power of enzymes. We report the atomic-resolution structure of a high-energy reaction intermediate stabilized in the active site of an enzyme. Crystallization of phosphorylated beta-phosphoglucomutase in the presence of the Mg(II) cofactor and either of the substrates glucose 1-phosphate or glucose 6-phosphate produced crystals of the enzyme-Mg(II)-glucose 1,6-(bis)phosphate complex, which diffracted x-rays to 1.2 and 1.4 angstroms, respectively. The structure reveals a stabilized pentacovalent phosphorane formed in the phosphoryl transfer from the C(1)O of glucose 1,6-(bis)phosphate to the nucleophilic Asp8 carboxylate.
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The line below this paragraph, {{ABSTRACT_PUBMED_12637673}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12637673 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12637673}}
==About this Structure==
==About this Structure==
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[[Category: Pentavalent phosphate intermediate]]
[[Category: Pentavalent phosphate intermediate]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:46:02 2008''

Revision as of 05:46, 29 July 2008

Image:1o08.png

Template:STRUCTURE 1o08

Structure of Pentavalent Phosphorous Intermediate of an Enzyme Catalyzed Phosphoryl transfer Reaction observed on cocrystallization with Glucose 1-phosphate

Template:ABSTRACT PUBMED 12637673

About this Structure

1O08 is a Single protein structure of sequence from Lactococcus lactis. Full crystallographic information is available from OCA.

Reference

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction., Lahiri SD, Zhang G, Dunaway-Mariano D, Allen KN, Science. 2003 Mar 28;299(5615):2067-71. Epub 2003 Mar 13. PMID:12637673

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