3bg5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bg5.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bg5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bg5| PDB=3bg5 | SCENE= }}
{{STRUCTURE_3bg5| PDB=3bg5 | SCENE= }}
-
'''Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase'''
+
===Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase===
-
==Overview==
+
<!--
-
Pyruvate carboxylase (PC) catalyzes the biotin-dependent production of oxaloacetate and has important roles in gluconeogenesis, lipogenesis, insulin secretion and other cellular processes. PC contains the biotin carboxylase (BC), carboxyltransferase (CT) and biotin-carboxyl carrier protein (BCCP) domains. We report here the crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC. A conserved tetrameric association is observed for both enzymes, and our structural and mutagenesis studies reveal a previously uncharacterized domain, the PC tetramerization (PT) domain, which is important for oligomerization. A BCCP domain is located in the active site of the CT domain, providing the first molecular insights into how biotin participates in the carboxyltransfer reaction. There are dramatic differences in domain positions in the monomer and the organization of the tetramer between these enzymes and the PC from Rhizobium etli.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18297087}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18297087 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18297087}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Pyruvate]]
[[Category: Pyruvate]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:38:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:47:55 2008''

Revision as of 05:47, 29 July 2008

Image:3bg5.png

Template:STRUCTURE 3bg5

Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase

Template:ABSTRACT PUBMED 18297087

About this Structure

3BG5 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction., Xiang S, Tong L, Nat Struct Mol Biol. 2008 Mar;15(3):295-302. Epub 2008 Feb 24. PMID:18297087

Page seeded by OCA on Tue Jul 29 08:47:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bg5"
Personal tools