This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2fuh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2fuh.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2fuh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2fuh| PDB=2fuh | SCENE= }}
{{STRUCTURE_2fuh| PDB=2fuh | SCENE= }}
-
'''Solution Structure of the UbcH5c/Ub Non-covalent Complex'''
+
===Solution Structure of the UbcH5c/Ub Non-covalent Complex===
-
==Overview==
+
<!--
-
Protein ubiquitination is a powerful regulatory modification that influences nearly every aspect of eukaryotic cell biology. The general pathway for ubiquitin (Ub) modification requires the sequential activities of a Ub-activating enzyme (E1), a Ub transfer enzyme (E2), and a Ub ligase (E3). The E2 must recognize both the E1 and a cognate E3 in addition to carrying activated Ub. These central functions are performed by a topologically conserved alpha/beta-fold core domain of approximately 150 residues shared by all E2s. However, as presented herein, the UbcH5 family of E2s can also bind Ub noncovalently on a surface well removed from the E2 active site. We present the solution structure of the UbcH5c/Ub noncovalent complex and demonstrate that this noncovalent interaction permits self-assembly of activated UbcH5c approximately Ub molecules. Self-assembly has profound consequences for the processive formation of polyubiquitin (poly-Ub) chains in ubiquitination reactions directed by the breast and ovarian cancer tumor susceptibility protein BRCA1.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16543155}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16543155 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16543155}}
==About this Structure==
==About this Structure==
-
2FUH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUH OCA].
+
2FUH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUH OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Lissounov, A.]]
[[Category: Lissounov, A.]]
[[Category: Protein-protein complex ubiquitin ubiquitin-conjugating enzyme]]
[[Category: Protein-protein complex ubiquitin ubiquitin-conjugating enzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:19:26 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:33 2008''

Revision as of 05:48, 29 July 2008

Image:2fuh.png

Template:STRUCTURE 2fuh

Solution Structure of the UbcH5c/Ub Non-covalent Complex

Template:ABSTRACT PUBMED 16543155

About this Structure

2FUH is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full experimental information is available from OCA.

Reference

A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination., Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE, Mol Cell. 2006 Mar 17;21(6):873-80. PMID:16543155

Page seeded by OCA on Tue Jul 29 08:48:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fuh"
Personal tools