2fuh

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[[Image:2fuh.gif|left|200px]]
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{{Seed}}
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[[Image:2fuh.png|left|200px]]
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{{STRUCTURE_2fuh| PDB=2fuh | SCENE= }}
{{STRUCTURE_2fuh| PDB=2fuh | SCENE= }}
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'''Solution Structure of the UbcH5c/Ub Non-covalent Complex'''
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===Solution Structure of the UbcH5c/Ub Non-covalent Complex===
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==Overview==
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Protein ubiquitination is a powerful regulatory modification that influences nearly every aspect of eukaryotic cell biology. The general pathway for ubiquitin (Ub) modification requires the sequential activities of a Ub-activating enzyme (E1), a Ub transfer enzyme (E2), and a Ub ligase (E3). The E2 must recognize both the E1 and a cognate E3 in addition to carrying activated Ub. These central functions are performed by a topologically conserved alpha/beta-fold core domain of approximately 150 residues shared by all E2s. However, as presented herein, the UbcH5 family of E2s can also bind Ub noncovalently on a surface well removed from the E2 active site. We present the solution structure of the UbcH5c/Ub noncovalent complex and demonstrate that this noncovalent interaction permits self-assembly of activated UbcH5c approximately Ub molecules. Self-assembly has profound consequences for the processive formation of polyubiquitin (poly-Ub) chains in ubiquitination reactions directed by the breast and ovarian cancer tumor susceptibility protein BRCA1.
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The line below this paragraph, {{ABSTRACT_PUBMED_16543155}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16543155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16543155}}
==About this Structure==
==About this Structure==
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2FUH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUH OCA].
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2FUH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUH OCA].
==Reference==
==Reference==
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[[Category: Lissounov, A.]]
[[Category: Lissounov, A.]]
[[Category: Protein-protein complex ubiquitin ubiquitin-conjugating enzyme]]
[[Category: Protein-protein complex ubiquitin ubiquitin-conjugating enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:19:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:33 2008''

Revision as of 05:48, 29 July 2008

Image:2fuh.png

Template:STRUCTURE 2fuh

Solution Structure of the UbcH5c/Ub Non-covalent Complex

Template:ABSTRACT PUBMED 16543155

About this Structure

2FUH is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full experimental information is available from OCA.

Reference

A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination., Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE, Mol Cell. 2006 Mar 17;21(6):873-80. PMID:16543155

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