1o97

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{{Seed}}
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{{STRUCTURE_1o97| PDB=1o97 | SCENE= }}
{{STRUCTURE_1o97| PDB=1o97 | SCENE= }}
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'''STRUCTURE OF ELECTRON TRANSFERRING FLAVOPROTEIN FROM METHYLOPHILUS METHYLOTROPHUS, RECOGNITION LOOP REMOVED BY LIMITED PROTEOLYSIS'''
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===STRUCTURE OF ELECTRON TRANSFERRING FLAVOPROTEIN FROM METHYLOPHILUS METHYLOTROPHUS, RECOGNITION LOOP REMOVED BY LIMITED PROTEOLYSIS===
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==Overview==
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Here we report the crystal structures of a ternary electron transfer complex showing extensive motion at the protein interface. This physiological complex comprises the iron-sulfur flavoprotein trimethylamine dehydrogenase and electron transferring flavoprotein (ETF) from Methylophilus methylotrophus. In addition, we report the crystal structure of free ETF. In the complex, electron density for the FAD domain of ETF is absent, indicating high mobility. Positions for the FAD domain are revealed by molecular dynamics simulation, consistent with crystal structures and kinetic data. A dual interaction of ETF with trimethylamine dehydrogenase provides for dynamical motion at the protein interface: one site acts as an anchor, thereby allowing the other site to sample a large range of interactions, some compatible with rapid electron transfer. This study establishes the role of conformational sampling in multi-domain redox systems, providing insight into electron transfer between ETFs and structurally distinct redox partners.
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The line below this paragraph, {{ABSTRACT_PUBMED_12567183}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12567183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12567183}}
==About this Structure==
==About this Structure==
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[[Category: Fad binding]]
[[Category: Fad binding]]
[[Category: Flavoprotein]]
[[Category: Flavoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:32:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:55 2008''

Revision as of 05:48, 29 July 2008

Image:1o97.png

Template:STRUCTURE 1o97

STRUCTURE OF ELECTRON TRANSFERRING FLAVOPROTEIN FROM METHYLOPHILUS METHYLOTROPHUS, RECOGNITION LOOP REMOVED BY LIMITED PROTEOLYSIS

Template:ABSTRACT PUBMED 12567183

About this Structure

1O97 is a Protein complex structure of sequences from Methylophilus methylotrophus. Full crystallographic information is available from OCA.

Reference

Extensive conformational sampling in a ternary electron transfer complex., Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS, Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183

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