1pqr

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[[Image:1pqr.jpg|left|200px]]
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[[Image:1pqr.png|left|200px]]
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{{STRUCTURE_1pqr| PDB=1pqr | SCENE= }}
{{STRUCTURE_1pqr| PDB=1pqr | SCENE= }}
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'''Solution Conformation of alphaA-Conotoxin EIVA'''
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===Solution Conformation of alphaA-Conotoxin EIVA===
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==Overview==
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We report the solution three-dimensional structure of an alphaA-conotoxin EIVA determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. The alphaA-conotoxin EIVA consists of 30 amino acids representing the largest peptide among the alpha/alphaA-family conotoxins discovered so far and targets the neuromuscular nicotinic acetylcholine receptor with high affinity. alphaA-Conotoxin EIVA consists of three distinct structural domains. The first domain is mainly composed of the Cys3-Cys11-disulfide loop and is structurally ill-defined with a large backbone root mean square deviation of 1.91 A. The second domain formed by residues His12-Hyp21 is extremely well defined with a backbone root mean square deviation of 0.52 A, thus forming a sturdy stem for the entire molecule. The third C-terminal domain formed by residues Hyp22-Gly29 shows an intermediate structural order having a backbone root mean square deviation of 1.04 A. A structurally ill-defined N-terminal first loop domain connected to a rigid central molecular stem seems to be the general structural feature of the alphaA-conotoxin subfamily. A detailed structural comparison between alphaA-conotoxin EIVA and alphaA-conotoxin PIVA suggests that the higher receptor affinity of alphaA-conotoxin EIVA than alphaA-conotoxin PIVA might originate from different steric disposition and charge distribution in the second loop "handle" motif.
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The line below this paragraph, {{ABSTRACT_PUBMED_12900418}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12900418 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12900418}}
==About this Structure==
==About this Structure==
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1PQR is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQR OCA].
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1PQR is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQR OCA].
==Reference==
==Reference==
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[[Category: C-term amidation]]
[[Category: C-term amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:22:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:50:05 2008''

Revision as of 05:50, 29 July 2008

Image:1pqr.png

Template:STRUCTURE 1pqr

Solution Conformation of alphaA-Conotoxin EIVA

Template:ABSTRACT PUBMED 12900418

About this Structure

1PQR is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus., Chi SW, Park KH, Suk JE, Olivera BM, McIntosh JM, Han KH, J Biol Chem. 2003 Oct 24;278(43):42208-13. Epub 2003 Aug 4. PMID:12900418

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