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1rpa

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[[Image:1rpa.gif|left|200px]]
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{{STRUCTURE_1rpa| PDB=1rpa | SCENE= }}
{{STRUCTURE_1rpa| PDB=1rpa | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF RAT ACID PHOSPHATASE IN COMPLEX WITH L(+) TARTRATE'''
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===THREE-DIMENSIONAL STRUCTURE OF RAT ACID PHOSPHATASE IN COMPLEX WITH L(+) TARTRATE===
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==Overview==
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The crystal structure of recombinant rat prostatic acid phosphatase in complex with the inhibitor L(+)-tartrate was determined to 3-A resolution with protein crystallographic methods. The inhibitor binds at the carboxyl end of the parallel strands of the alpha/beta domain. One of the carboxyl groups of the tartrate molecule interacts with the conserved residues Arg-11, His-12, and Arg-15, which form part of the phosphate binding site. Furthermore, the C2 and C3 hydroxyl groups interact with His-257 and Arg-79. The second carboxyl group is close to Arg-79 but makes no direct hydrogen bonds to the protein. A sequence comparison between tartrate-sensitive and -resistant acid phosphatases suggests that these enzymes have different three-dimensional structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 8407898 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8407898}}
==About this Structure==
==About this Structure==
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[[Category: Lindqvist, Y.]]
[[Category: Lindqvist, Y.]]
[[Category: Schneider, G.]]
[[Category: Schneider, G.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:45:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:52:25 2008''

Revision as of 05:52, 29 July 2008

Image:1rpa.png

Template:STRUCTURE 1rpa

THREE-DIMENSIONAL STRUCTURE OF RAT ACID PHOSPHATASE IN COMPLEX WITH L(+) TARTRATE

Template:ABSTRACT PUBMED 8407898

About this Structure

1RPA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of rat acid phosphatase in complex with L(+)-tartrate., Lindqvist Y, Schneider G, Vihko P, J Biol Chem. 1993 Oct 5;268(28):20744-6. PMID:8407898

Page seeded by OCA on Tue Jul 29 08:52:25 2008

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