2bez

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{{STRUCTURE_2bez| PDB=2bez | SCENE= }}
{{STRUCTURE_2bez| PDB=2bez | SCENE= }}
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'''STRUCTURE OF A PROTEOLITICALLY RESISTANT CORE FROM THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS S2 FUSION PROTEIN'''
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===STRUCTURE OF A PROTEOLITICALLY RESISTANT CORE FROM THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS S2 FUSION PROTEIN===
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==Overview==
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A coronavirus (CoV) has recently been identified as the causative agent of the severe acute respiratory syndrome (SARS) in humans. CoVs enter target cells through fusion of viral and cellular membranes mediated by the viral envelope glycoprotein S. We have determined by x-ray crystallography the structure of a proteolytically stable core fragment from the heptad repeat (HR) regions HR1 and HR2 of the SARS-CoV S protein. We have also determined the structure of an HR1-HR2 S core fragment, containing a shorter HR1 peptide and a C-terminally longer HR2 peptide that extends up to the transmembrane region. In these structures, three HR1 helices form a parallel coiled-coil trimer, whereas three HR2 peptides pack in an oblique and antiparallel fashion into the coiled-coil hydrophobic grooves, adopting mixed extended and alpha-helical conformations as in postfusion paramyxoviruses F proteins structures. Our structure positions a previously proposed internal fusion peptide adjacent to the N-terminus of HR1. Peptides from the HR2 region of SARS-CoV S have been shown to inhibit viral entry and infection in vitro. The structures presented here can thus open the path to the design of small-molecule inhibitors of viral entry and candidate vaccine antigens against this virus.
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(as it appears on PubMed at http://www.pubmed.gov), where 15604146 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15604146}}
==About this Structure==
==About this Structure==
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[[Category: Supekar, V M.]]
[[Category: Supekar, V M.]]
[[Category: Coiled coil,membrane fusion,severe acute respiratory syndrome,viral protein]]
[[Category: Coiled coil,membrane fusion,severe acute respiratory syndrome,viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:12:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:00:14 2008''

Revision as of 06:00, 29 July 2008

Image:2bez.png

Template:STRUCTURE 2bez

STRUCTURE OF A PROTEOLITICALLY RESISTANT CORE FROM THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS S2 FUSION PROTEIN

Template:ABSTRACT PUBMED 15604146

About this Structure

2BEZ is a Protein complex structure of sequences from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein., Supekar VM, Bruckmann C, Ingallinella P, Bianchi E, Pessi A, Carfi A, Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17958-63. Epub 2004 Dec 16. PMID:15604146

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