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1w9h

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{{STRUCTURE_1w9h| PDB=1w9h | SCENE= }}
{{STRUCTURE_1w9h| PDB=1w9h | SCENE= }}
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'''THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS.'''
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===THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS.===
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==Overview==
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RNA silencing regulates gene expression through mRNA degradation, translation repression and chromatin remodelling. The fundamental engines of RNA silencing are RISC and RITS complexes, whose common components are 21-25 nt RNA and an Argonaute protein containing a PIWI domain of unknown function. The crystal structure of an archaeal Piwi protein (AfPiwi) is organised into two domains, one resembling the sugar-binding portion of the lac repressor and another with similarity to RNase H. Invariant residues and a coordinated metal ion lie in a pocket that surrounds the conserved C-terminus of the protein, defining a key functional region in the PIWI domain. Furthermore, two Asp residues, conserved in the majority of Argonaute sequences, align spatially with the catalytic Asp residues of RNase H-like catalytic sites, suggesting that in eukaryotic Argonaute proteins the RNase H-like domain may possess nuclease activity. The conserved region around the C-terminus of the PIWI domain, which is required for small interfering RNA (siRNA) binding to AfPiwi, may function as the receptor site for the obligatory 5' phosphate of siRNAs, thereby specifying the cleavage position of the target mRNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15565169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15565169}}
==About this Structure==
==About this Structure==
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[[Category: Risc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:20:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:00:35 2008''

Revision as of 06:00, 29 July 2008

Image:1w9h.png

Template:STRUCTURE 1w9h

THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS.

Template:ABSTRACT PUBMED 15565169

About this Structure

1W9H is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity., Parker JS, Roe SM, Barford D, EMBO J. 2004 Dec 8;23(24):4727-37. Epub 2004 Nov 25. PMID:15565169

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