1ndn

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{{STRUCTURE_1ndn| PDB=1ndn | SCENE= }}
{{STRUCTURE_1ndn| PDB=1ndn | SCENE= }}
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'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''
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===MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4===
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==Overview==
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The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides, has been determined by x-ray diffraction analysis at 3 A resolution. The molecule adopts a B-DNA conformation, not unlike those found in intact dodecamer DNA molecules crystallized in a somewhat different crystal lattice, despite a gap due to the absence of a phosphate group in the molecule. The helix has a distinct narrow minor groove near the center of the molecule at the AAAA region. This suggests that the internal stabilizing forces due to base stacking and hydrogen-bonding interactions are sufficient to overcome the loss of connectivity associated with the disruption of the covalent backbone of DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 2320572 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2320572}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Nicked]]
[[Category: Nicked]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:06:31 2008''

Revision as of 06:06, 29 July 2008

Image:1ndn.png

Template:STRUCTURE 1ndn

MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4

Template:ABSTRACT PUBMED 2320572

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:2320572

Page seeded by OCA on Tue Jul 29 09:06:31 2008

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