1zpx

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[[Image:1zpx.gif|left|200px]]
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{{STRUCTURE_1zpx| PDB=1zpx | SCENE= }}
{{STRUCTURE_1zpx| PDB=1zpx | SCENE= }}
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'''NMR Structure of Mcol1-[13-33] from Hydra'''
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===NMR Structure of Mcol1-[13-33] from Hydra===
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==Overview==
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Synthetic replicates of naturally occurring cysteine-rich peptides such as hormones, neurotransmitters, growth factors, enzyme inhibitors, defensins and toxins often can be oxidatively folded in high yields to their native structure in simple redox buffers. Thereby, identical cysteine patterns in the sequence were found to generate identical disulfide connectivities and homologous spatial structures despite significant variability in the non-cysteine positions. Minicollagen-1 from the nematocysts of Hydra is a trimeric protein that contains cysteine-rich domains at the N and C termini, which are involved in the assembly of an intermolecular disulfide network. Determination of the three-dimensional structures of peptides corresponding to the N-terminal and C-terminal domains by NMR spectroscopy revealed a remarkable exception from the general rule. Despite an identical cysteine pattern, the two domains of minicollagen-1 form different disulfide bridges and exhibit distinctly different folds, both of which are not found in the current structural databases. To our knowledge, this is the first case where two relatively short peptides with the abundant cysteine residues in identical sequence positions fold uniquely and with high yields into defined, but differing, structures. Therefore, the cysteine-rich domains of minicollagen constitute ideal model systems for studies of the interplay between folding and oxidation in proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16257007 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16257007}}
==About this Structure==
==About this Structure==
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1ZPX is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPX OCA].
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1ZPX is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPX OCA].
==Reference==
==Reference==
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[[Category: Renner, C.]]
[[Category: Renner, C.]]
[[Category: Cysteine-rich peptide]]
[[Category: Cysteine-rich peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:09:45 2008''

Revision as of 06:09, 29 July 2008

Image:1zpx.png

Template:STRUCTURE 1zpx

NMR Structure of Mcol1-[13-33] from Hydra

Template:ABSTRACT PUBMED 16257007

About this Structure

1ZPX is a Single protein structure. Full experimental information is available from OCA.

Reference

The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern., Milbradt AG, Boulegue C, Moroder L, Renner C, J Mol Biol. 2005 Dec 2;354(3):591-600. Epub 2005 Oct 14. PMID:16257007

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