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2bld

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{{STRUCTURE_2bld| PDB=2bld | SCENE= }}
{{STRUCTURE_2bld| PDB=2bld | SCENE= }}
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'''THE QUASI-ATOMIC MODEL OF HUMAN ADENOVIRUS TYPE 5 CAPSID (PART 1)'''
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===THE QUASI-ATOMIC MODEL OF HUMAN ADENOVIRUS TYPE 5 CAPSID (PART 1)===
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==Overview==
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Adenoviruses infect a wide range of vertebrates including humans. Their icosahedral capsids are composed of three major proteins: the trimeric hexon forms the facets and the penton, a noncovalent complex of the pentameric penton base and trimeric fibre proteins, is located at the 12 capsid vertices. Several proteins (IIIa, VI, VIII and IX) stabilise the capsid. We have obtained a 10 A resolution map of the human adenovirus 5 by image analysis from cryo-electron micrographs (cryoEMs). This map, in combination with the X-ray structures of the penton base and hexon, was used to build a quasi-atomic model of the arrangement of the two major capsid components and to analyse the hexon-hexon and hexon-penton interactions. The secondary proteins, notably VIII, were located by comparing cryoEM maps of native and pIX deletion mutant virions. Minor proteins IX and IIIa are located on the outside of the capsid, whereas protein VIII is organised with a T=2 lattice on the inner face of the capsid. The capsid organisation is compared with the known X-ray structure of bacteriophage PRD1.
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(as it appears on PubMed at http://www.pubmed.gov), where 15861131 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15861131}}
==About this Structure==
==About this Structure==
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[[Category: Quasi atomic]]
[[Category: Quasi atomic]]
[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:27:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:10:04 2008''

Revision as of 06:10, 29 July 2008

Image:2bld.png

Template:STRUCTURE 2bld

THE QUASI-ATOMIC MODEL OF HUMAN ADENOVIRUS TYPE 5 CAPSID (PART 1)

Template:ABSTRACT PUBMED 15861131

About this Structure

2BLD is a Protein complex structure of sequences from Human adenovirus 2. Full crystallographic information is available from OCA.

Reference

A quasi-atomic model of human adenovirus type 5 capsid., Fabry CM, Rosa-Calatrava M, Conway JF, Zubieta C, Cusack S, Ruigrok RW, Schoehn G, EMBO J. 2005 May 4;24(9):1645-54. Epub 2005 Apr 21. PMID:15861131

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