1qmu

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{{STRUCTURE_1qmu| PDB=1qmu | SCENE= }}
{{STRUCTURE_1qmu| PDB=1qmu | SCENE= }}
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'''DUCK CARBOXYPEPTIDASE D DOMAIN II'''
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===DUCK CARBOXYPEPTIDASE D DOMAIN II===
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==Overview==
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The crystal structure of domain II of duck carboxypeptidase D, a prohormone/propeptide processing enzyme integrated in a three repeat tandem in the natural system, has been solved, constituting a prototype for members of the regulatory metallocarboxypeptidase subfamily. It displays a 300 residue N-terminal alpha/beta-hydrolase subdomain with overall topological similarity to and general coincidence of the key catalytic residues with the archetypal pancreatic carboxypeptidase A. However, numerous significant insertions/deletions in segments forming the funnel-like access to the active site explain differences in specificity towards larger protein substrates or inhibitors. This alpha/beta-hydrolase subdomain is followed by a C-terminal 80 residue beta-sandwich subdomain, unique for these regulatory metalloenzymes and topologically related to transthyretin and sugar-binding proteins. The structure described here establishes the fundamentals for a better understanding of the mechanism ruling events such as prohormone processing and will enable modelling of regulatory carboxypeptidases as well as a more rational design of inhibitors of carboxypeptidase D.
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(as it appears on PubMed at http://www.pubmed.gov), where 10545093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10545093}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Zinc-dependent protease]]
[[Category: Zinc-dependent protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:27:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:10:26 2008''

Revision as of 06:10, 29 July 2008

Image:1qmu.png

Template:STRUCTURE 1qmu

DUCK CARBOXYPEPTIDASE D DOMAIN II

Template:ABSTRACT PUBMED 10545093

About this Structure

1QMU is a Single protein structure of sequence from Anas specularioides. Full crystallographic information is available from OCA.

Reference

Crystal structure of avian carboxypeptidase D domain II: a prototype for the regulatory metallocarboxypeptidase subfamily., Gomis-Ruth FX, Companys V, Qian Y, Fricker LD, Vendrell J, Aviles FX, Coll M, EMBO J. 1999 Nov 1;18(21):5817-26. PMID:10545093

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