2hua

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[[Image:2hua.gif|left|200px]]
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{{STRUCTURE_2hua| PDB=2hua | SCENE= }}
{{STRUCTURE_2hua| PDB=2hua | SCENE= }}
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'''Solution Structure of CSFV IRES Domain IIa'''
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===Solution Structure of CSFV IRES Domain IIa===
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==Overview==
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Internal ribosome entry site (IRES) RNAs from the hepatitis C virus (HCV) and classical swine fever virus (CSFV) coordinate cap-independent assembly of eukaryotic 48S initiation complexes, consisting of the 40S ribosomal subunit, eukaryotic initiation factor (eIF) 3 and the eIF2/GTP/Met-tRNA(i)(Met) ternary complex. Here, we report that these IRESes also play a functional role during 80S ribosome assembly downstream of 48S complex formation, in promoting eIF5-induced GTP hydrolysis and eIF2/GDP release from the initiation complex. We show that this function is encoded in their independently folded IRES domain II and that it depends both on its characteristic bent conformation and two conserved RNA motifs, an apical hairpin loop and a loop E. Our data suggest a general mode of subunit joining in HCV and HCV-like IRESes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17255934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17255934}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA].
==Reference==
==Reference==
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[[Category: Lukavsky, P J.]]
[[Category: Lukavsky, P J.]]
[[Category: Rna hairpin]]
[[Category: Rna hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:43:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:11:00 2008''

Revision as of 06:11, 29 July 2008

Image:2hua.png

Template:STRUCTURE 2hua

Solution Structure of CSFV IRES Domain IIa

Template:ABSTRACT PUBMED 17255934

About this Structure

Full experimental information is available from OCA.

Reference

HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly., Locker N, Easton LE, Lukavsky PJ, EMBO J. 2007 Feb 7;26(3):795-805. Epub 2007 Jan 25. PMID:17255934

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