2gk7

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{{STRUCTURE_2gk7| PDB=2gk7 | SCENE= }}
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'''Structural and Functional insights into the human Upf1 helicase core'''
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===Structural and Functional insights into the human Upf1 helicase core===
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==Overview==
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Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway that recognizes and degrades aberrant mRNAs containing premature stop codons. A critical protein in NMD is Upf1p, which belongs to the helicase super family 1 (SF1), and is thought to utilize the energy of ATP hydrolysis to promote transitions in the structure of RNA or RNA-protein complexes. The crystal structure of the catalytic core of human Upf1p determined in three states (phosphate-, AMPPNP- and ADP-bound forms) reveals an overall structure containing two RecA-like domains with two additional domains protruding from the N-terminal RecA-like domain. Structural comparison combined with mutational analysis identifies a likely single-stranded RNA (ssRNA)-binding channel, and a cycle of conformational change coupled to ATP binding and hydrolysis. These conformational changes alter the likely ssRNA-binding channel in a manner that can explain how ATP binding destabilizes ssRNA binding to Upf1p.
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(as it appears on PubMed at http://www.pubmed.gov), where 17159905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17159905}}
==About this Structure==
==About this Structure==
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[[Category: Nmd]]
[[Category: Nmd]]
[[Category: Upf1]]
[[Category: Upf1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:12:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:11:47 2008''

Revision as of 06:11, 29 July 2008

Image:2gk7.png

Template:STRUCTURE 2gk7

Structural and Functional insights into the human Upf1 helicase core

Template:ABSTRACT PUBMED 17159905

About this Structure

2GK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into the human Upf1 helicase core., Cheng Z, Muhlrad D, Lim MK, Parker R, Song H, EMBO J. 2007 Jan 10;26(1):253-64. Epub 2006 Dec 7. PMID:17159905

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