2qzt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2qzt.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2qzt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2qzt| PDB=2qzt | SCENE= }}
{{STRUCTURE_2qzt| PDB=2qzt | SCENE= }}
-
'''Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti'''
+
===Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti===
-
==Overview==
+
<!--
-
Mosquito sterol carrier protein-2 (AeSCP-2) and sterol carrier protein-2-like2 (AeSCP-2L2) are members of the SCP-2 protein family with similar expression profiles in the mosquito life cycle. In an effort to understand how lipids can be transported by different SCP-2 proteins, the three-dimensional crystal structure of AeSCP-2L2 was solved at 1.7 A resolution. AeSCP-2L2 forms a dimer and binds three fatty acids, one of which resides in a position within the internal cavity at a right angle to the others. This first report of ligand-bound dimerized protein in the SCP-2 protein family indicates that the family has a much more divergent mode of interaction with ligands than previously reported. The potential function of AeSCP-2L2 was investigated via in vivo incorporation of [(3)H]cholesterol and [(3)H]palmitic acid. Overexpression of AeSCP-2L2 in mosquito cells leads to an increased uptake of free fatty acid, whereas knockdown of AeSCP-2L2 in adult females decreases the accumulation of free fatty acid in the fat body from a blood meal. In contrast, overexpression or knockdown of AeSCP-2L2 has no effect on cholesterol uptake. Our results suggest that the main function of AeSCP-2L2 is as a general intracellular fatty acid carrier, as opposed to having a dedicated role in cholesterol transport.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18084051}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18084051 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18084051}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Palmitic acid]]
[[Category: Palmitic acid]]
[[Category: Sterol carrier]]
[[Category: Sterol carrier]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:59:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:18:03 2008''

Revision as of 06:18, 29 July 2008

Image:2qzt.png

Template:STRUCTURE 2qzt

Crystal Structure of Sterol Carrier Protein 2 Like 2 (SCP2-L2) from Aedes Aegypti

Template:ABSTRACT PUBMED 18084051

About this Structure

2QZT is a Single protein structure of sequence from Aedes aegypti. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members., Dyer DH, Wessely V, Forest KT, Lan Q, J Lipid Res. 2008 Mar;49(3):644-53. Epub 2007 Dec 15. PMID:18084051

Page seeded by OCA on Tue Jul 29 09:18:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qzt"
Personal tools