1qhv

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[[Image:1qhv.jpg|left|200px]]
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{{Seed}}
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[[Image:1qhv.png|left|200px]]
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{{STRUCTURE_1qhv| PDB=1qhv | SCENE= }}
{{STRUCTURE_1qhv| PDB=1qhv | SCENE= }}
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'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD'''
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===HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD===
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==Overview==
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Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_10502512}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10502512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10502512}}
==About this Structure==
==About this Structure==
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[[Category: Extra-ordinary stability]]
[[Category: Extra-ordinary stability]]
[[Category: Receptor binding]]
[[Category: Receptor binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:17:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:21:28 2008''

Revision as of 06:21, 29 July 2008

Image:1qhv.png

Template:STRUCTURE 1qhv

HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD

Template:ABSTRACT PUBMED 10502512

About this Structure

1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.

Reference

Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512

Page seeded by OCA on Tue Jul 29 09:21:28 2008

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