2pyy

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{{STRUCTURE_2pyy| PDB=2pyy | SCENE= }}
{{STRUCTURE_2pyy| PDB=2pyy | SCENE= }}
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'''Crystal Structure of the GluR0 ligand-binding core from Nostoc punctiforme in complex with (L)-glutamate'''
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===Crystal Structure of the GluR0 ligand-binding core from Nostoc punctiforme in complex with (L)-glutamate===
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==Overview==
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GluR0 from Nostoc punctiforme (NpGluR0) is a bacterial homologue of the ionotropic glutamate receptor (iGluR). We have solved the crystal structure of the ligand-binding core of NpGluR0 in complex with l-glutamate at a resolution of 2.1 A. The structure exhibits a noncanonical ligand interaction and two distinct subunit interfaces. The side-chain guanidium group of Arg80 forms a salt bridge with the gamma-carboxyl group of bound L-glutamate: in GluR0 from Synechocystis (SGluR0) and other iGluRs, the equivalent residues are Asn or Thr, which cannot form a similar interaction. We suggest that the local positively charged environment and the steric constraint created by Arg80 mediate the selectivity of L-glutamate binding by preventing the binding of positively charged and hydrophobic amino acids. In addition, the NpGluR0 ligand-binding core forms a new subunit interface in which the two protomers are arranged differently than the known iGluR and SGluR0 dimer interfaces. The significance of there being two different dimer interfaces was investigated using analytical ultracentrifugation analysis.
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{{ABSTRACT_PUBMED_18164033}}
==About this Structure==
==About this Structure==
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[[Category: Glur0 ligand binding domain]]
[[Category: Glur0 ligand binding domain]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:02:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:22:44 2008''

Revision as of 06:22, 29 July 2008

Image:2pyy.png

Template:STRUCTURE 2pyy

Crystal Structure of the GluR0 ligand-binding core from Nostoc punctiforme in complex with (L)-glutamate

Template:ABSTRACT PUBMED 18164033

About this Structure

2PYY is a Single protein structure of sequence from Nostoc punctiforme. Full crystallographic information is available from OCA.

Reference

Crystal structure of the GluR0 ligand-binding core from Nostoc punctiforme in complex with L-glutamate: structural dissection of the ligand interaction and subunit interface., Lee JH, Kang GB, Lim HH, Jin KS, Kim SH, Ree M, Park CS, Kim SJ, Eom SH, J Mol Biol. 2008 Feb 15;376(2):308-16. Epub 2007 Nov 6. PMID:18164033

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