2gxb

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{{STRUCTURE_2gxb| PDB=2gxb | SCENE= }}
{{STRUCTURE_2gxb| PDB=2gxb | SCENE= }}
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'''Crystal Structure of The Za Domain bound to Z-RNA'''
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===Crystal Structure of The Za Domain bound to Z-RNA===
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==Overview==
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The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.
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The line below this paragraph, {{ABSTRACT_PUBMED_17437712}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17437712 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17437712}}
==About this Structure==
==About this Structure==
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[[Category: Z-rna]]
[[Category: Z-rna]]
[[Category: Za]]
[[Category: Za]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:38:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:30:20 2008''

Revision as of 06:30, 29 July 2008

Image:2gxb.png

Template:STRUCTURE 2gxb

Crystal Structure of The Za Domain bound to Z-RNA

Template:ABSTRACT PUBMED 17437712

About this Structure

2GXB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712

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