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2hdl

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[[Image:2hdl.jpg|left|200px]]
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{{STRUCTURE_2hdl| PDB=2hdl | SCENE= }}
{{STRUCTURE_2hdl| PDB=2hdl | SCENE= }}
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'''Solution structure of Brak/CXCL14'''
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===Solution structure of Brak/CXCL14===
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==Overview==
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The chemokine CXCL14/BRAK participates in immune surveillance by recruiting dendritic cells. CXCL14 gene expression is altered in a number of cancers, but protein expression levels have not been investigated. Here we report that CXCL14 protein can be expressed in primary epithelial cells; however, in several immortalized and cancer cell lines this protein is targeted for polyubiquitylation and proteasomal degradation. We determined the NMR structure of CXCL14 to identify motifs controlling its expression. CXCL14 adopts the canonical chemokine tertiary fold but contains a unique five amino acid insertion (41VSRYR45) relative to other CXC chemokines. Deletion or substitution of key residues within this insertion prevented proteasomal degradation. Furthermore, we defined a 15 amino acid fragment of CXCL14 that is sufficient to induce proteasomal degradation. This study elucidates a post-translational mechanism for the loss of CXCL14 in cancer and a novel mode of chemokine regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16987528 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16987528}}
==About this Structure==
==About this Structure==
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2HDL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDL OCA].
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2HDL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDL OCA].
==Reference==
==Reference==
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[[Category: Cxcl14]]
[[Category: Cxcl14]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:09:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:31:46 2008''

Revision as of 06:31, 29 July 2008

Image:2hdl.png

Template:STRUCTURE 2hdl

Solution structure of Brak/CXCL14

Template:ABSTRACT PUBMED 16987528

About this Structure

2HDL is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome., Peterson FC, Thorpe JA, Harder AG, Volkman BF, Schwarze SR, J Mol Biol. 2006 Nov 3;363(4):813-22. Epub 2006 Aug 26. PMID:16987528

Page seeded by OCA on Tue Jul 29 09:31:46 2008

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