2hkn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hkn.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2hkn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hkn| PDB=2hkn | SCENE= }}
{{STRUCTURE_2hkn| PDB=2hkn | SCENE= }}
-
'''Crystal structure of the CAP-Gly domain of human Dynactin-1 (p150-Glued)'''
+
===Crystal structure of the CAP-Gly domain of human Dynactin-1 (p150-Glued)===
-
==Overview==
+
<!--
-
Dynamic microtubule plus-end tracking protein (+TIP) networks are implicated in all functions of microtubules, but the molecular determinants of their interactions are largely unknown. Here, we have explored key binding modes of +TIPs by analyzing the interactions between selected CAP-Gly, EB-like, and carboxy-terminal EEY/F-COO(-) sequence motifs. X-ray crystallography and biophysical binding studies demonstrate that the beta2-beta3 loop of CAP-Gly domains determines EB-like motif binding specificity. They further show how CAP-Gly domains serve as recognition domains for EEY/F-COO(-) motifs, which represent characteristic and functionally important sequence elements in EB, CLIP-170, and alpha-tubulin. Our findings provide a molecular basis for understanding the modular interaction modes between alpha-tubulin, CLIPs, EB proteins, and the dynactin-dynein motor complex and suggest that multiple low-affinity binding sites in different combinations control dynamic +TIP networks at microtubule ends. They further offer insights into the structural consequences of genetic CAP-Gly domain defects found in severe human disorders.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16949363}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16949363 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16949363}}
==Disease==
==Disease==
Line 33: Line 37:
[[Category: P150-glued]]
[[Category: P150-glued]]
[[Category: Strand swap]]
[[Category: Strand swap]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:24:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:37:09 2008''

Revision as of 06:37, 29 July 2008

Image:2hkn.png

Template:STRUCTURE 2hkn

Contents

Crystal structure of the CAP-Gly domain of human Dynactin-1 (p150-Glued)

Template:ABSTRACT PUBMED 16949363

Disease

Known disease associated with this structure: Neuropathy, distal hereditary motor, type VIIB OMIM:[601143], Amyotrophic lateral sclerosis, susceptibility to OMIM:[601143]

About this Structure

2HKN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Key interaction modes of dynamic +TIP networks., Honnappa S, Okhrimenko O, Jaussi R, Jawhari H, Jelesarov I, Winkler FK, Steinmetz MO, Mol Cell. 2006 Sep 1;23(5):663-71. PMID:16949363

Page seeded by OCA on Tue Jul 29 09:37:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hkn"
Personal tools