1yvf

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{{Seed}}
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{{STRUCTURE_1yvf| PDB=1yvf | SCENE= }}
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'''Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145'''
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===Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145===
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==Overview==
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A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.
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(as it appears on PubMed at http://www.pubmed.gov), where 15863301 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15863301}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:42:07 2008''

Revision as of 06:42, 29 July 2008

Image:1yvf.png

Template:STRUCTURE 1yvf

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

Template:ABSTRACT PUBMED 15863301

About this Structure

Full crystallographic information is available from OCA.

Reference

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:15863301

Page seeded by OCA on Tue Jul 29 09:42:07 2008

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