1t4w

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{{STRUCTURE_1t4w| PDB=1t4w | SCENE= }}
{{STRUCTURE_1t4w| PDB=1t4w | SCENE= }}
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'''Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1'''
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===Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1===
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==Overview==
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The DNA binding domains of human p53 and Cep-1, its C. elegans ortholog, recognize essentially identical DNA sequences despite poor sequence similarity. We solved the three-dimensional structure of the Cep-1 DNA binding domain in the absence of DNA and compared it to that of human p53. The two domains have similar overall folds. However, three loops, involved in DNA and Zn binding in human p53, contain small alpha helices in Cep-1. The alpha helix in loop L3 of Cep-1 orients the side chains of two conserved arginines toward DNA; in human p53, both arginines are mutation hotspots, but only one contacts DNA. The alpha helix in loop L1 of Cep-1 repositions the entire loop, making it unlikely for residues of this loop to contact bases in the major groove of DNA, as occurs in human p53. Thus, during evolution there have been considerable changes in the structure of the p53 DNA binding domain.
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{{ABSTRACT_PUBMED_15242600}}
==About this Structure==
==About this Structure==
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[[Category: Stavridi, E S.]]
[[Category: Stavridi, E S.]]
[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:31:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:43:07 2008''

Revision as of 06:43, 29 July 2008

Image:1t4w.png

Template:STRUCTURE 1t4w

Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1

Template:ABSTRACT PUBMED 15242600

About this Structure

1T4W is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1., Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD, Structure. 2004 Jul;12(7):1237-43. PMID:15242600

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