1s5z

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[[Image:1s5z.gif|left|200px]]
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{{Seed}}
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[[Image:1s5z.png|left|200px]]
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{{STRUCTURE_1s5z| PDB=1s5z | SCENE= }}
{{STRUCTURE_1s5z| PDB=1s5z | SCENE= }}
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'''NDP kinase in complex with adenosine phosphonoacetic acid'''
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===NDP kinase in complex with adenosine phosphonoacetic acid===
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==Overview==
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NDP kinase catalyzes the last step in the phosphorylation of nucleotides. It is also involved in the activation by cellular kinases of nucleoside analogs used in antiviral therapies. Adenosine phosphonoacetic acid, a close analog of ADP already proposed as an inhibitor of ribonucleotide reductase, was found to be a poor substrate for human NDP kinase, as well as a weak inhibitor with an equilibrium dissociation constant of 0.6 mM to be compared to 0.025 mM for ADP. The X-ray structure of a complex of adenosine phosphonoacetic acid and the NDP kinase from Dictyostelium was determined to 2.0 A resolution showing that the analog adopts a binding mode similar to ADP, but that no magnesium ion is present at the active site. As ACP may also interfere with other cellular kinases, its potential as a drug targeting NDP kinase or ribonucleotide reductase is likely to be limited due to strong side effects. The design of new molecules with a narrower specificity and a stronger affinity will benefit from the detailed knowledge of the complex ACP-NDP kinase.
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The line below this paragraph, {{ABSTRACT_PUBMED_16787337}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16787337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16787337}}
==About this Structure==
==About this Structure==
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[[Category: Veron, M.]]
[[Category: Veron, M.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:20:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:43:33 2008''

Revision as of 06:43, 29 July 2008

Image:1s5z.png

Template:STRUCTURE 1s5z

NDP kinase in complex with adenosine phosphonoacetic acid

Template:ABSTRACT PUBMED 16787337

About this Structure

1S5Z is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase., Chen Y, Morera S, Pasti C, Angusti A, Solaroli N, Veron M, Janin J, Manfredini S, Deville-Bonne D, Med Chem. 2005 Nov;1(6):529-36. PMID:16787337

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